Objective

The course aims to provide graduate students in MSc. or Ph.D. programs in Biomedicine, Biology, Biotechnology and Chemistry, from our country and the region (South America), with an integrated and updated view of mitochondrial physiology and its role in cell biology and pathology; along with methodologies to study mitochondrial bioenergetics, dynamics and oxidant formation.

Students

Priority will be given to graduate students whose projects or study interests align with the course theme. Undergraduate students with significant progress in their studies who can justify their interest in taking the course will also be accepted.

A limited number of partial scholarships will be awarded to students who are not residents of Montevideo, Uruguay. Interested applicants may request a scholarship when applying for the course.

Teachers

Organizing Committee

• Dr.  Adriana Cassina, CEINBIO y Departamento de Bioquímica, Facultad de Medicina, Universidad de la República
• Dr. Laura Castro, CEINBIO y Departamento de Bioquímica, Facultad de Medicina, Universidad de la República
• Dr. Celia Quijano, CEINBIO y Departamento de Bioquímica, Facultad de Medicina, Universidad de la República

International Speakers

• Dr. César Cárdenas
  Center for Integrative Biology, Faculty of Sciences, Universidad Mayor and Geroscience Center for Brain Health and Metabolism Santiago, Chile
  Department of Chemistry and Biochemistry, University of California Santa Barbara, and Buck Institute for Research on Aging, Novato, USA
• Dr. Natalia de Isla
  Biopôle de l’Université de Lorraine, Faculté de Médecine, Ingénierie Moléculaire, Cellulaire et Physiopathologie (IMOPA), Centre national de la recherche scientifique (CNRS), Nancy, France
• Dr. Nadine Hempel
  Department of Medicine, Division of Hematology & Oncology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
• Dr. Diana Jurk
  Department of Physiology Biomedical Engineering, and Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
• Dr. Joao Passos
  Department of Physiology and Biomedical Engineering and Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA
• Dr. Janine Santos
  Mechanistic Toxicology Branch, Division of Translational, Toxicology, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Durham, North Carolina, USA
• Dr. Javier Santos
  Instituto de Biociencias, Biotecnología y Biología Translacional, Facultad de Ciencias Exactas, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

National Speakers

• Dr. Miguel Arocena, Departamento de Biología Odontológica, Facultad de Odontología, Universidad de la República
• Dr. Sebastián Carballal, Departamento de Bioquímica, Facultad de Medicina, Universidad de la República
• Dr. Patricia Cassina, Departamento de Histología y Embriología, Facultad de Medicina, Universidad de la República
• Dr. Alfredo Cerisola, Centro de Referencia Nacional de Defectos Congénitos y Enfermedades Raras, BPS y Unidad Académica de Neuropediatría, Facultad de Medicina, Universidad de la República
• Dr. Verónica Demicheli, Departamento de Bioquímica, Facultad de Medicina, Universidad de la República
• Dr. Carlos Escande, Laboratorio de Metabolismo y Envejecimiento, Institut Pasteur de Montevideo
• Dr. Mercedes García-Roche, Departamento de Producción animal y pasturas, Facultad de Agronomía, Universidad de la República
• Dra. Pilar Irigoyen, Departamento de Histología y Embriología, Facultad de Medicina, Universidad de la República
• Dr. Santiago Mansilla, Departamento de Métodos Cuantitativos, Facultad de Medicina, Universidad de la República
• Dr. Inés Marmisolle, Departamento de Bioquímica, Facultad de Medicina, Universidad de la República
• Dr. Jennyfer Matínez, Departamento de Bioquímica, Facultad de Medicina, Universidad de la República
• Dr. Laura Martínez-Palma, Departamento de Histología y Embriología, Facultad de Medicina, Universidad de la República
• Dr. Ernesto Miquel, Departamento de Histología y Embriología, Facultad de Medicina, Universidad de la República
• Dr. Rafael Radi, Departamento de Bioquímica, Facultad de Medicina, Universidad de la República
• Dr. Victor Raggio, Departamento de Genética, Facultad de Medicina, Universidad de la República
• Dr. Verónica Tórtora, Departamento de Educación Médica, Facultad de Medicina, Universidad de la República
• Dr. Valeria Valez, Departamento de Biología Odontológica, Facultad de Odontología, Universidad de la República
• Dr. Ari Zeida, Departamento de Bioquímica, Facultad de Medicina, Universidad de la República

Host Institution

Centro de investigaciones Biomédicas (CEINBIO), Departamento de Bioquímica, Facultad de Medicina, Universidad de la República

Dates

• Start: Monday, June 2^nd, 2025
• End: Friday, June 13^th, 2025

Timetable

Monday, June 2^nd

08:45-09:00 Registration

09:00-10:00  Welcome & Mitochondria: much more than the cellular energy central - Dr. Celia Quijano

10:15-11:15 Electron transport and oxidative phosphorylation - Dr. Adriana Cassina/Dr. Mercedes García-Roche

11:15-11:30 Coffee break

11:30-12:30 Formation and detection of mitochondrial oxidants - Dr. Laura Castro

12:30-14:00 Free for lunch

14:00-15:00 Mitochondrial DNA and primary mitochondrial diseases  - Dr. Víctor Raggio

15:15-16:15 Mitochondrial lipids - Dr. Verónica Demicheli

16:15-16:30 Coffee break

16:30-17:30 Distribution of Papers & Practical Activities
 

Tuesday, June 3^rd

09:00-10:00 Nicotinamide adenine dinucleotide (NAD⁺/NADH) in mitochondria and cell metabolism - Dr. Carlos Escande

10:15-11:15 Mitochondrial dynamics - Dr. Jennyfer Martínez

11:15-11:30 Coffee break

11:30-12:30 Mitochondrial biogenesis and autophagy - Dr. Mercedes García-Roche

12:30-14:00 Free for lunch

14:00-15:00 Mitochondria in cell death - Dr. Miguel Arocena

15:15-16:15 Energy metabolism of nervous system cells and neurodegenerative diseases  - Dr. Patricia Cassina

16:15-16:30 Coffee break

16:30-17:30 Nitric oxide and hydrogen sulfide in the mitochondria - Dr. Sebastián Carballal
 

Wednesday, June 4^th

09:00-17:30 Practical activity

1. Evaluation of mitochondrial function in isolated mitochondria and tissues (Dr. M. García-Roche, Dr. V. Valez and Dr. A. Cassina).
2. Evaluation of Energy Metabolism in Cultured Cells (Dr. I. Marmisolle and Dr. C. Quijano).
3. Formation of hydrogen peroxide by isolated mitochondria and evaluation of mitochondrial enzyme activity (Dr. V. Tortora, Dr. P. Irigoyen and Dr. L. Castro).
4. Study of mitochondrial morphology in cultured cells (Dr. J. Martínez, Dr. L. Martínez-Palma and Dr. E. Miquel).
5. Analysis of mitochondrial protein structure (Dr. S. Mansilla, Dr. J. Santos, Dr. A. Zeida).
    

Thursday, June 5^th

09:00-17:30 Practical activity

1. Evaluation of mitochondrial function in isolated mitochondria and tissues (Dr. M. García-Roche, Dr. V. Valez and Dr. A. Cassina).
2. Evaluation of Energy Metabolism in Cultured Cells (Dr. I. Marmisolle and Dr. C. Quijano).
3. Formation of hydrogen peroxide by isolated mitochondria and evaluation of mitochondrial enzyme activity (Dr. V. Tortora, Dr. P. Irigoyen and Dr. L. Castro).
4. Study of mitochondrial morphology in cultured cells (Dr. J. Martínez, Dr. L. Martínez-Palma and Dr. E. Miquel).
5. Analysis of mitochondrial protein structure (Dr. S. Mansilla, Dr. J. Santos, Dr. A. Zeida).
    

Friday, June 6^th

09:00-12:30 Results presentation and discussion

12:30-14:00 Free for lunch

14:00-17:30 Results presentation and discussion
 

Monday, June 9^th

09:00-10:00 Iron-sulfur clusters biogenesis, structure and function  - Dr. Javier Santos

10:15-11:15 Seminar 1 - Dr. Javier Santos

11:15-11:30 Coffee break

11:30-12:30 Seminar 2 - Dr. Janine Santos

12:30-14:00 Free for lunch

14:00-15:00 Seminar 3 - Dr. Natalia de Isla

15:15-16:15 Seminar 4 - Dr. César Cárdenas

16:15-16:30 Coffee break

16:30-17:30 Seminar 5 - Dr. Nadine Hempel

17:30-18:30 Seminar 6 - Dr. Joao Passos
 

Tuesday, June 10^th

9:00-10:00 Role of mitochondria-endoplasmic reticulum contacts (MERCs) - Dr. Cesar Cárdenas

10:15-11:15 Broad means of mitochondrial communication: the role of DNA, metabolites and lipids - Dr. Janine Santos

11:15-11:30 Coffee break

11:30-12:30 Mitochondrial transfer mechanisms - Dr. Natalia de Isla

12:30-14:00 Free for lunch

14:00-15:00 Mitochondria redox signaling in cancer - Dr. Nadine Hempel

15:15-16:15 Mitochondria, metabolism and aging - Dr. Joao Passos

16:15-16:30 Coffee break

16:30-17:30 Mitochondria-targeted therapeutics  - Dr. Rafael Radi
 

Wednesday, June 11^th

Symposium Mitochondria and cell biology - check time table here >>>

Thursday, June 12^th

Symposium Mitochondria and cell biology - check time table here >>>
 

Friday, June 13^th

10:00 - 12:00 - EVALUATION

Supporting Institutions

Programa en Alimentos y Salud Humana (PAyS), Centro de Investigaciones Biomédicas (CEINBIO), Departamento de Bioquímica de la Facultad de Medicina, Programa para la Investigación Biomédica (Pro.In.Bio), Comisión Sectorial de Investigación Científica (CSIC), Universidad de la República; Programa de Desarrollo de las Ciencias Básicas (PEDECIBA); Agencia Nacional de Investigación e Innovación (ANII); Centro Latinoamericano de Biotecnología (CABBIO); Programa ECOS-Sud Uruguay-Francia; Society for Redox Biology and Medicine (SfRBM).

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Registration

Students interested in applying must complete the form by Sunday, April 6th, 2025, at 11:59 PM.

For further information, please feel free to contact us to curso_mitocondria@ceinbio.edu.uy